Aarhus University (AU) (Denmark)

AU logoNo positions available.

PROJECT NO. 1 – PhD position

Project title: Selecting small molecule binders from modified DNA junctions.

Project description: A new strategy for the preparation of aptamers containing chemical modifications will be investigated for the development of a new class of aptamers with higher affinity for their target.

Requirements: The applicant for this project should hold a master (or equivalent) in chemistry, molecular biology or nanotechnology, The applicant should ideally have practical experience in conjugation of small molecules to DNA, organic synthesis and basic molecular biology techniques such as PCR and PAGE.

Contact: Professor Kurt Gothelf; kvg@chem.au.dk; Interdisciplinary Nanoscience Center, Aarhus University, Denmark

Application deadline: Call is closed

Application site: Call is closed

PROJECT NO. 2 – PhD position

Project title: DNA origami vehicles for drug delivery

Project description: Design of DNA origami containers and global chemical modification of their surface to make them (a) impenetrable to the molecular cargo until unlocked, (b) less degradable, and (c) able to recognize and penetrate target cells. We will apply modified PAMAM dendrimers attached to stable strands as anchor points for further functionalization and cross-linking of the surface DNA origami.

Requirements: The applicant for this project should hold a master (or equivalent) in nanotechnology, chemistry or molecular biology. The applicant should ideally have experience with design and preparation of DNA structures and conjugation of molecules to DNA. Practical experience with cell cultures is also desirable.

Contact: Professor Kurt Gothelf; kvg@chem.au.dk; Interdisciplinary Nanoscience Center, Aarhus University, Denmark

Application deadline: Call is closed

Application site: Call is closed

PROJECT NO. 3 – PhD position

Project title: DNA origami devices for controlling enzymatic activity

Project description: DNA origami devices will be designed and used to control enzyme activity at a single molecule level. DNA-enzyme units will be assembled into programmable and dynamic arrays for precise control of consecutive enzymatic reactions on the same substrate, thereby enabling complex multistep synthesis in a one-tube reaction.

Requirements: The applicant should hold a background in molecular biology, biochemistry or nanotechnology preferably with practical experience in molecular cloning, protein expression and purification, and enzymatic assays. Detailed knowledge of DNA/RNA/protein biochemistry, macromolecular self-assembly and biomolecular computing will be necessary for execution of the project.

Contact: Professor Jørgen Kjems; jk@mb.au.dk; Department of Molecular Biology and Genetics, Interdisciplinary Nanoscience Center, Aarhus University, Denmark. Assistant professor Ebbe Sloth Andersen; esa@inano.au.dk, Interdisciplinary Nanoscience Center, Aarhus University, Denmark

Application deadline: Call is closed

Application site: Call is closed