University of Oxford (UOXF) (UK)

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PROJECT NO. 10 – PhD POSITION

Project title: Dynamic DNA Structures for Control of Biological Systems.

Project description: One of the most exciting properties of DNA nanostructures is their ability to change shape and move in response to external stimuli. We propose to design dynamic nanostructures – molecular robots – that are functionalized to mediate interaction with biological molecules and structures and to explore their potential to exert active control over their environments outside and within cells. Potential stimuli for shape change include DNA and RNA and, through incorporation of specific aptamers, proteins and small molecules such as ATP, creating the possibility of structures that respond to biologically relevant stimuli. The project will include secondment to Ludwig Maximilians University.

Requirements: Relevant research experience could include: nanofabrication by self-assembly; synthetic biology; biochemistry, cellular or molecular biology; biophysical characterization of cellular and biomolecular systems. At the time of recruitment the candidate must: be in the first 4 years of their research career; have not yet been awarded a doctoral degree; have not resided or carried out their main activity in the U.K. for more than 12 months in the previous 3 years. The candidate must be qualified to study for an Oxford D.Phil. as either a first or second research degree.

Contact: Professor Andrew Turberfielda.turberfield@physics.ox.ac.uk; Department of Physics, University of Oxford, UK

Application deadline: Call is closed

Application siteCall is closed

PROJECT NO. 11 – PhD POSITION

Project title: DNA structures for functional control of proteins.

Project description: We will investigate the ability of DNA cages to deliver protein cargos within cells and to control their activity by selectively impeding or facilitating their interaction with other large biomolecules, potentially creating smart drug delivery vehicles. Cages will be functionalized to facilitate targeting and interaction with the membrane, and that the cage-opening activation mechanism can also be independently engineered without requiring modification of the cargo.

Requirements: Relevant research experience could include: nanofabrication by self-assembly; biochemistry, cellular or molecular biology, including work on biological membranes; biological chemistry; biophysical characterization of cellular and biomolecular systems. At the time of recruitment the candidate must: be in the first 4 years of their research career; have not yet been awarded a doctoral degree; have not resided or carried out their main activity in the U.K. for more than 12 months in the previous 3 years. The candidate must be qualified to study for an Oxford D.Phil. as either a first or second research degree. The project will include secondment to Aarhus University.

Contact: Professor Andrew Turberfielda.turberfield@physics.ox.ac.uk; Department of Physics, University of Oxford, UK

Application deadline: Call is closed

Application siteCall is closed

PROJECT NO. 14 – PhD POSITION

Project title: Computation by and operation of synthetic molecular motors made from DNA.

Project description: We will develop computing systems based on DNA automata, capable of controlled motion, navigating self-assembled networks of tracks. Applications include biomolecular computation, molecular systems for analysis and local control of chemical synthesis including drug manufacture or delivery. The project will include secondment to Microsoft Research Cambridge to work on the development of software tools for automated design and verification.

Requirements: A high level of competence in computer programming is essential. Desirable research experience includes some of: computer science, including automated techniques for design and verification; nanofabrication by self-assembly; synthetic biology; chemistry; biophysical characterization of cellular and biomolecular systems. At the time of recruitment the candidate must: be in the first 4 years of their research career; have not yet been awarded a doctoral degree; have not resided or carried out their main activity in the U.K. for more than 12 months in the previous 3 years. The candidate must be qualified to study for an Oxford D.Phil. as either a first or second research degree.

Contact: Professor Andrew Turberfielda.turberfield@physics.ox.ac.uk; Department of Physics, University of Oxford, UK

Application deadline: Call is closed

Application site:  Call is closed